TM9SF2

Across TCGA patient cohorts, TM9SF2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,822 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TM9SF2-associated genes across cancer lineages are FILIP1, ETS1, and LRRC8C. Each is linked with TM9SF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TM9SF2-to-partner and partner-to-TM9SF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TM9SF2 versus FILIP1 in CCRCC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF2→partner) and Y-score (partner→TM9SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FILIP1 →	-0.726	-0.287	<.001	<.001	3	5
CCRCC	ETS1 →	-0.751	-0.364	<.001	<.001	3	5
BRCA	LRRC8C →	-0.663	-0.502	<.001	.003	3	5
CCRCC	DDHD2 →	-0.539	-0.447	<.001	<.001	3	5
OV	ALG5 →	+0.522	+0.315	.007	.002	3	4
OV	WDR17 →	-0.628	-0.287	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,822 associations by consensus.

TM9SF2 vs FILIP1 — CCRCC

Explore this scatter interactively →