TM9SF2

Across TCGA pan-cancer cohorts, TM9SF2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TM9SF2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TM9SF2 RNA is repressed in tumor relative to normal tissue. In most cancer types TM9SF2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, STAD, and THCA are the cancer types where TM9SF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TM9SF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.995	<.001	9	view →
STAD	Male	II,III,IV	+0.900	<.001	8	view →
THCA	Male	III,IV	−0.784	<.001	8	view →
BLCA	All	III,IV	+0.772	<.001	8	view →
HNSC	All	All	+0.489	<.001	6	view →
KIRC	Male	III,IV	−0.435	.008	6	view →
BRCA	Female	II,III,IV	+0.404	<.001	6	view →
CHOL	All	II,III,IV	+1.865	.010	4	view →
LIHC	All	All	+0.548	<.001	4	view →
LUSC	Female	II,III,IV	−0.727	.005	3	view →
PAAD	All	All	+0.602	.041	2	view →
COAD	Male	All	+0.399	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TM9SF2–KICH

Open the KICH breakdown →