TM4SF4

Across TCGA cell cohorts, TM4SF4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TM4SF4-associated genes across cancer lineages are KCNK16, TEX33, and C1orf185. Each is linked with TM4SF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF4-to-partner and partner-to-TM4SF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK16 grouped by TM4SF4-low versus TM4SF4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF4→partner) and Y-score (partner→TM4SF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KCNK16 →	+0.040	+5.000	.007	.006	3	1
LUNG_NSCLC_LUAD	TEX33 →	+0.036	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C1orf185 →	+0.063	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4D10 →	+0.053	+5.662	<.001	.002	3	1
LARGE_INTESTINE	TBC1D3 →	+0.123	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KCNK16 by TM4SF4 expression — PANCREAS

Explore this box plot interactively →