TM4SF4

Across TCGA pan-cancer cohorts, TM4SF4 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated TM4SF4 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TM4SF4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TM4SF4 expression acts as an unfavorable survival marker, although some lineages such as MESO and ACC show a favorable association.

MESO, ACC, and THCA are the cancer types where TM4SF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.669	0.355	<.001	60	view →
ACC	DFS	Tertile	II,III,IV	0.666	0.126	.002	32	view →
THCA	OS	Median	All	0.999	0.980	.003	28	view →
LGG	OS	Median	All	0.359	0.625	<.001	25	view →
KIRP	DFS	Median	IV	0.041	0.683	.009	23	view →
ESCA	OS	Median	All	0.659	1.000	.020	12	view →
LUAD	OS	Quartile	II,III,IV	0.590	0.738	.027	12	view →
KICH	DFS	Quartile	III,IV	0.904	0.251	.010	11	view →
STAD	OS	Tertile	III,IV	0.262	0.663	.019	9	view →
COAD	OS	Median	IV	0.263	0.783	.007	9	view →
CHOL	DFS	Median	II,III,IV	0.220	0.708	.049	3	view →
HNSC	DFS	Quartile	III,IV	0.309	0.548	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

TM4SF4–MESO (OS)

Open the MESO breakdown →