TM4SF20

Across TCGA patient cohorts, TM4SF20 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF20-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and VHL. Each is linked with TM4SF20 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF20-to-partner and partner-to-TM4SF20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TM4SF20-low versus TM4SF20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF20→partner) and Y-score (partner→TM4SF20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+3.000	.045	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.591	-2.986	.023	.037	3	1
UCEC	VHL →	-0.939	-3.000	.016	.036	3	1
UCEC	NDRG1_pT346 →	-0.626	-3.000	.027	.037	2	1
UCEC	JNK_pT183_Y185 →	-0.238	-2.986	.014	.037	1	1
UCEC	PCNA →	+0.323	+3.000	.009	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by TM4SF20 expression — UCEC

Explore this box plot interactively →