TM4SF20

Across TCGA pan-cancer cohorts, TM4SF20 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TM4SF20’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TM4SF20 RNA is repressed in tumor relative to normal tissue. In most cancer types TM4SF20 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where TM4SF20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TM4SF20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.104	<.001	7	view →
KICH	Male	All	−0.054	<.001	6	view →
LIHC	All	All	+1.041	<.001	4	view →
COAD	Female	All	−1.540	.002	3	view →
ESCA	All	II,III,IV	+5.490	.044	2	view →
KIRC	All	All	−0.013	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TM4SF20–THCA

Open the THCA breakdown →