TM4SF20

Across TCGA pan-cancer cohorts, TM4SF20 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TM4SF20 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TM4SF20 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TM4SF20 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

ACC, LUAD, and UVM are the cancer types where TM4SF20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.774	0.956	.005	89	view →
LUAD	OS	Quartile	II,III,IV	0.590	0.762	.001	76	view →
UVM	DFS	Median	All	0.509	0.858	.001	46	view →
LIHC	OS	Median	III,IV	0.424	0.781	<.001	25	view →
BLCA	DFS	Quartile	III,IV	0.336	0.468	.010	24	view →
KIRC	OS	Median	All	0.835	0.903	.019	22	view →
LGG	DFS	Quartile	All	0.944	0.768	.003	19	view →
STAD	DFS	Tertile	III,IV	0.394	0.675	.007	12	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
UCS	DFS	Median	III,IV	0.560	0.277	.009	12	view →
THCA	OS	Median	II,III,IV	0.992	0.962	.015	11	view →
SCLC	OS	Tertile	II,III,IV	0.982	0.289	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TM4SF20–ACC (OS)

Open the ACC breakdown →