TLR9

Across TCGA patient cohorts, TLR9 mutation is significantly associated with the RNA expression of many other genes, with 3,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR9-associated genes across cancer lineages are GSKIP, PLTP, and BNIP3L. Each is linked with TLR9 in more than 2 cancer types. Because this analysis shows association rather than direction, both TLR9-to-partner and partner-to-TLR9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSKIP grouped by TLR9-low versus TLR9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR9→partner) and Y-score (partner→TLR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSKIP →	+0.376	+1.671	.001	.007	3	3
UCEC	PLTP →	-0.818	-1.830	<.001	<.001	3	3
COAD	BNIP3L →	+0.719	+3.598	.004	.001	3	3
UCEC	TLE6 →	+0.644	+1.807	<.001	.003	3	3
BRCA	VN1R54P →	+0.557	+4.062	<.001	.004	3	3
UCEC	KDM5C-IT1 →	+0.127	+1.602	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,129 associations by consensus.

GSKIP by TLR9 expression — UCEC

Explore this box plot interactively →