TLR9

Across TCGA pan-cancer cohorts, TLR9 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TLR9 data layer compared with 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TLR9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TLR9 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

UCEC, SKCM, and KIRC are the cancer types where TLR9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.574	0.779	<.001	90	view →
SKCM	OS	Tertile	All	0.852	0.730	<.001	84	view →
KIRC	DFS	Quartile	IV	0.278	0.576	.003	64	view →
ACC	DFS	Median	All	0.416	0.777	.001	42	view →
READ	DFS	Tertile	All	0.368	0.732	.001	40	view →
LIHC	DFS	Median	All	0.471	0.604	.002	36	view →
HNSC	DFS	Quartile	III,IV	0.757	0.529	.003	31	view →
OV	OS	Tertile	IV	0.494	0.878	<.001	30	view →
UCS	DFS	Tertile	IV	0.978	0.403	.024	30	view →
LUSC	DFS	Tertile	III,IV	0.241	0.862	.010	28	view →
TGCT	DFS	Quartile	II,III,IV	0.603	0.996	.034	18	view →
CESC	DFS	Quartile	All	0.752	0.887	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TLR9–UCEC (OS)

Open the UCEC breakdown →