Across TCGA cell cohorts, TLR5 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLR5-associated genes across cancer lineages are KNG1, STRA8, and OR1L6. Each is linked with TLR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR5-to-partner and partner-to-TLR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR5→partner) and Y-score (partner→TLR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KNG1 →	+0.917	+3.920	<.001	.005	3	1
LUNG_NSCLC_LUAD	STRA8 →	+0.431	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.028	+5.247	<.001	<.001	3	1
LUNG_NSCLC_LUAD	NCR1 →	+0.071	+4.628	<.001	.001	3	1
SKIN	KHDC3L →	+0.018	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

TLR5 survival (RNA) · tumor vs normal (RNA) · all TLR5 data types