TLL2

Across TCGA cell cohorts, TLL2 mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLL2-associated genes across cancer lineages are GPR26, C10orf71, and OR56A1. Each is linked with TLL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLL2-to-partner and partner-to-TLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by TLL2-low versus TLL2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLL2→partner) and Y-score (partner→TLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	2
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	OR56A1 →	+0.030	+4.523	.001	.004	3	1
BLOOD_Lymphoma	RBMY1A1 →	+0.013	+5.794	.006	<.001	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	IFNL4 →	+0.032	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

GPR26 by TLL2 expression — OESOPHAGUS

Explore this box plot interactively →