TLL2

Across TCGA pan-cancer cohorts, TLL2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TLL2 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TLL2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TLL2 expression acts as an unfavorable survival marker, although some lineages such as CESC and CHOL show a favorable association.

KIRC, UVM, and ACC are the cancer types where TLL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.548	0.709	<.001	149	view →
UVM	DFS	Median	All	0.314	0.790	<.001	130	view →
ACC	DFS	Median	All	0.252	0.630	<.001	85	view →
CESC	OS	Median	II,III,IV	0.677	0.276	<.001	70	view →
LIHC	OS	Quartile	All	0.521	0.816	<.001	53	view →
HNSC	OS	Tertile	III,IV	0.641	0.791	.001	51	view →
THCA	OS	Median	All	0.892	0.983	.001	48	view →
LUAD	DFS	Median	All	0.682	0.844	.002	36	view →
CHOL	DFS	Median	II,III,IV	0.690	0.151	.004	30	view →
UCS	OS	Tertile	IV	0.308	0.679	.024	18	view →
THYM	DFS	Tertile	All	0.932	0.763	.012	15	view →
LGG	OS	Quartile	All	0.387	0.605	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TLL2–KIRC (OS)

Open the KIRC breakdown →