TLE7

Across TCGA patient cohorts, TLE7 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,197 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TLE7-associated GO terms across cancer lineages are Regulation of intrinsic apoptotic signaling pathway, Blastocyst development, and Animal organ regeneration. Each is linked with TLE7 in more than 10 cancer types. Because this analysis shows association rather than direction, both TLE7-to-partner and partner-to-TLE7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intrinsic apoptotic signaling pathway grouped by TLE7-low versus TLE7-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE7→partner) and Y-score (partner→TLE7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of intrinsic apoptotic signaling pathway →	+0.086	+0.194	<.001	<.001	3	11
STAD	Blastocyst development →	+0.071	+0.167	<.001	<.001	3	10
STAD	Animal organ regeneration →	+0.083	+0.209	<.001	<.001	3	10
STAD	Regulation of endosome size →	+0.069	+0.167	<.001	<.001	3	9
STAD	Chaperone-mediated protein folding →	+0.090	+0.161	<.001	<.001	3	9
STAD	Regulation of mitochondrial gene expression →	+0.078	+0.157	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,197 associations by consensus.

Regulation of intrinsic apoptotic signaling pathway by TLE7 expression — STAD

Explore this box plot interactively →