TLE7

Across TCGA pan-cancer cohorts, TLE7 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TLE7 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TLE7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TLE7 expression acts as an unfavorable survival marker, although some lineages such as PRAD and SKCM show a favorable association.

BRCA, LUSC, and DLBC are the cancer types where TLE7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.907	0.966	<.001	60	view →
LUSC	OS	Tertile	All	0.233	0.422	.008	60	view →
DLBC	DFS	Tertile	II,III,IV	0.338	0.825	.004	58	view →
KIRC	DFS	Tertile	All	0.286	0.649	<.001	42	view →
CHOL	OS	Tertile	All	0.024	0.675	<.001	36	view →
UCEC	OS	Tertile	III,IV	0.356	0.642	.002	36	view →
COAD	OS	Tertile	IV	0.089	0.676	<.001	36	view →
KICH	DFS	Tertile	II,III,IV	0.035	0.860	<.001	27	view →
THYM	OS	Tertile	All	0.535	0.921	.004	18	view →
PRAD	DFS	Tertile	All	1.000	0.751	.021	18	view →
SARC	OS	Tertile	All	0.716	0.847	.003	18	view →
THCA	OS	Tertile	IV	0.579	1.000	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TLE7–BRCA (OS)

Open the BRCA breakdown →