Across TCGA cell cohorts, TLE7 RNA expression is significantly associated with the mutation status of many other genes, with 748 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLE7-associated genes across cancer lineages are UHRF1BP1, SMYD1, and GATAD2A. Each is linked with TLE7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLE7-to-partner and partner-to-TLE7 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE7→partner) and Y-score (partner→TLE7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	UHRF1BP1 →	+4.807	+0.006	.006	<.001	3	2
BLOOD_Leukemia	SMYD1 →	+5.969	+0.022	.001	<.001	3	2
BLOOD_Lymphoma	GATAD2A →	+5.643	+0.016	.002	<.001	3	2
BLOOD_Lymphoma	CDC42BPB →	+4.058	+0.009	.009	<.001	3	2
BLOOD_Leukemia	VWCE →	+3.969	+0.021	.009	<.001	3	2
BLOOD_Leukemia	ALMS1 →	+2.384	+0.008	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 748 associations by consensus.

Exploration

TLE7 survival (RNA) · tumor vs normal (RNA) · all TLE7 data types