TLE5

Across TCGA cell cohorts, TLE5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,497 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TLE5-associated GO terms across cancer lineages are Energy coupled proton transmembrane transport, against electrochemical gradient, Electron transport coupled proton transport, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with TLE5 in more than 14 cancer types. Because this analysis shows association rather than direction, both TLE5-to-partner and partner-to-TLE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy coupled proton transmembrane transport, against electrochemical gradient grouped by TLE5-low versus TLE5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLE5→partner) and Y-score (partner→TLE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.094	+0.833	.001	<.001	3	15
OESOPHAGUS	Electron transport coupled proton transport →	+0.094	+0.833	.001	<.001	3	15
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.145	+0.903	<.001	<.001	3	13
SKIN	Mitochondrial tRNA methylation →	-0.081	-0.835	<.001	<.001	3	10
BONE	Negative regulation of protein localization to chromatin →	+0.155	+0.936	<.001	<.001	3	10
BLOOD_Lymphoma	Positive regulation of protein localization to chromatin →	+0.128	+0.911	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,497 associations by consensus.

Energy coupled proton transmembrane transport, against electrochemical gradient by TLE5 expression — OESOPHAGUS

Explore this box plot interactively →