TLE5

Across TCGA pan-cancer cohorts, TLE5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TLE5 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TLE5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TLE5 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

STAD, UCEC, and UVM are the cancer types where TLE5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	III,IV	0.700	0.443	<.001	89	view →
UCEC	DFS	Tertile	All	0.817	0.524	.001	68	view →
UVM	DFS	Tertile	III,IV	1.000	0.427	<.001	54	view →
ACC	DFS	Tertile	All	0.249	0.693	<.001	49	view →
LGG	OS	Median	All	0.755	0.864	<.001	36	view →
UCS	OS	Median	III,IV	0.448	0.716	.023	24	view →
CESC	OS	Median	II,III,IV	0.687	0.423	.027	24	view →
BLCA	DFS	Tertile	All	0.697	0.543	.001	23	view →
CHOL	OS	Median	II,III,IV	0.901	0.413	.008	22	view →
HNSC	OS	Quartile	All	0.796	0.634	.005	20	view →
SCLC	DFS	Median	III,IV	0.658	0.349	.012	20	view →
PAAD	OS	Quartile	All	0.581	0.247	.011	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TLE5–STAD (DFS)

Open the STAD breakdown →