TLE5

Across TCGA pan-cancer cohorts, TLE5 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TLE5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TLE5 RNA is repressed in tumor relative to normal tissue. In most cancer types TLE5 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, LIHC, and BLCA are the cancer types where TLE5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLE5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.631	<.001	9	view →
LIHC	Female	II,III,IV	+1.000	<.001	7	view →
BLCA	All	III,IV	−0.664	.007	6	view →
UCEC	All	All	−0.643	<.001	6	view →
LUSC	Male	All	−0.495	<.001	6	view →
CHOL	All	All	+1.900	<.001	5	view →
HNSC	All	All	−0.304	.005	3	view →
READ	All	All	−0.446	.006	2	view →
PRAD	All	All	−0.278	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TLE5–LUAD

Open the LUAD breakdown →