TKT

Across TCGA patient cohorts, TKT mutation is significantly associated with the RNA expression of many other genes, with 2,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TKT-associated genes across cancer lineages are SNORD91B, MTCYBP5, and PABPC1L2B-AS1. Each is linked with TKT in more than 1 cancer types. Because this analysis shows association rather than direction, both TKT-to-partner and partner-to-TKT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD91B grouped by TKT-low versus TKT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKT→partner) and Y-score (partner→TKT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD91B →	+0.282	+1.622	.006	.008	3	2
LUAD	MTCYBP5 →	+0.068	+5.343	<.001	.006	3	2
COAD	PABPC1L2B-AS1 →	+0.023	+5.412	<.001	.001	3	2
UCEC	POLR3K →	+0.493	+3.928	<.001	<.001	3	2
UCEC	TRAPPC2L →	+0.448	+2.598	<.001	<.001	3	2
UCEC	PGAM1 →	+0.635	+2.436	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,060 associations by consensus.

SNORD91B by TKT expression — UCEC

Explore this box plot interactively →