TKFC

Across TCGA patient cohorts, TKFC RNA expression is significantly associated with the RNA expression of many other genes, with 19,000 significant associations in total. ACC shows the largest number of these associations.

The most reproducible TKFC-associated genes across cancer lineages are GPR137, INTS5, and TMEM179B. Each is linked with TKFC in more than 32 cancer types. Because this analysis shows association rather than direction, both TKFC-to-partner and partner-to-TKFC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TKFC versus GPR137 in SCLC, with a Pearson correlation of 0.47.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TKFC→partner) and Y-score (partner→TKFC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	GPR137 →	+1.875	+0.560	<.001	<.001	3	33
ACC	INTS5 →	+0.728	+0.893	<.001	<.001	3	32
ACC	TMEM179B →	+1.059	+1.238	<.001	<.001	3	32
ACC	PAAF1 →	+1.076	+1.257	<.001	<.001	3	32
UVM	FOXRED1 →	+0.862	+0.868	<.001	<.001	3	32
KICH	SLC24A1 →	+1.313	+0.836	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,000 associations by consensus.

TKFC vs GPR137 — SCLC

Explore this scatter interactively →