TKFC

Across TCGA pan-cancer cohorts, TKFC RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TKFC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TKFC RNA is repressed in tumor relative to normal tissue. In most cancer types TKFC is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where TKFC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TKFC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.727	<.001	11	view →
KIRP	Male	III,IV	−1.398	<.001	11	view →
KIRC	Male	All	−0.790	<.001	11	view →
COAD	Male	II,III,IV	+0.990	<.001	9	view →
BLCA	All	III,IV	+0.739	<.001	8	view →
HNSC	Male	III,IV	+0.725	<.001	8	view →
LUAD	Female	II,III,IV	+0.515	<.001	8	view →
LUSC	Female	All	+0.955	<.001	7	view →
BRCA	All	III,IV	+0.791	<.001	6	view →
LIHC	All	All	−0.720	<.001	5	view →
THCA	Male	All	−0.210	.012	5	view →
CHOL	All	All	−1.707	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TKFC–KICH

Open the KICH breakdown →