TIPIN

Across TCGA patient cohorts, TIPIN mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIPIN-associated genes across cancer lineages are EGFR_pY1068, ERK2, and JNK_pT183_Y185. Each is linked with TIPIN in more than 1 cancer types. Because this analysis shows association rather than direction, both TIPIN-to-partner and partner-to-TIPIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TIPIN-low versus TIPIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIPIN→partner) and Y-score (partner→TIPIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.584	.018	.010	3	1
UCEC	ERK2 →	+0.189	+2.222	.020	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-3.584	.002	.002	3	1
UCEC	MSH2 →	-0.232	-2.973	.017	.035	3	1
UCEC	mTOR_pS2448 →	-0.160	-2.439	.011	.019	3	1
UCEC	Notch1 →	+0.168	+3.179	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by TIPIN expression — UCEC

Explore this box plot interactively →