TIMM17B

Across TCGA patient cohorts, TIMM17B mutation is significantly associated with the RNA expression of many other genes, with 3,565 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM17B-associated genes across cancer lineages are RNU4-58P, LIN7C, and DGKZ. Each is linked with TIMM17B in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM17B-to-partner and partner-to-TIMM17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by TIMM17B-low versus TIMM17B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM17B→partner) and Y-score (partner→TIMM17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.285	+3.034	<.001	<.001	3	2
UCEC	LIN7C →	+0.578	+2.815	.001	.001	3	1
UCEC	DGKZ →	+0.368	+3.818	.002	<.001	3	1
UCEC	SSRP1 →	+0.652	+3.960	<.001	<.001	3	1
UCEC	INTS4 →	+0.366	+3.024	.001	<.001	3	1
UCEC	NPAT →	+0.602	+2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,565 associations by consensus.

RNU4-58P by TIMM17B expression — UCEC

Explore this box plot interactively →