TIMM17B

Across TCGA pan-cancer cohorts, TIMM17B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TIMM17B data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TIMM17B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TIMM17B expression acts as an unfavorable survival marker, although some lineages such as OV and SCLC show a favorable association.

KICH, LIHC, and OV are the cancer types where TIMM17B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.347	0.942	.001	90	view →
LIHC	OS	Median	All	0.695	0.863	<.001	57	view →
OV	DFS	Median	IV	0.589	0.302	<.001	28	view →
SCLC	OS	Tertile	III,IV	0.578	0.273	.010	25	view →
UCS	OS	Tertile	IV	0.294	0.883	.024	24	view →
LUAD	DFS	Quartile	III,IV	0.389	0.854	.009	23	view →
BRCA	OS	Tertile	All	0.899	0.950	.013	20	view →
KIRC	OS	Median	All	0.840	0.916	.012	19	view →
LGG	DFS	Tertile	All	0.890	0.776	.001	18	view →
KIRP	DFS	Quartile	All	0.458	0.926	.002	18	view →
ACC	DFS	Tertile	III,IV	0.763	0.173	<.001	17	view →
CESC	OS	Median	All	0.906	0.838	.018	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TIMM17B–KICH (OS)

Open the KICH breakdown →