TIGD4

Across TCGA patient cohorts, TIGD4 mutation is significantly associated with the RNA expression of many other genes, with 3,483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD4-associated genes across cancer lineages are RPL12P5, MIR4774, and RNA5SP93. Each is linked with TIGD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD4-to-partner and partner-to-TIGD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P5 grouped by TIGD4-low versus TIGD4-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD4→partner) and Y-score (partner→TIGD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL12P5 →	+0.131	+5.219	<.001	.006	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
BLCA	RNA5SP93 →	+0.182	+5.632	<.001	.001	3	2
UCEC	CUEDC1 →	+0.573	+1.680	<.001	<.001	3	2
UCEC	C8orf33 →	+0.474	+1.648	.001	.001	3	2
UCEC	RP9P →	+0.525	+2.684	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,483 associations by consensus.

RPL12P5 by TIGD4 expression — READ

Explore this box plot interactively →