TIGD4

Across TCGA pan-cancer cohorts, TIGD4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TIGD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TIGD4 RNA is repressed in tumor relative to normal tissue. In most cancer types TIGD4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where TIGD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIGD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.060	<.001	10	view →
KIRC	All	III,IV	−0.303	<.001	9	view →
COAD	Male	All	+0.929	<.001	8	view →
LIHC	Male	All	+0.140	<.001	6	view →
STAD	All	All	+0.336	.005	4	view →
LUSC	All	II,III,IV	−0.326	.013	3	view →
ESCA	All	II,III,IV	+1.135	.004	2	view →
CHOL	All	All	+0.396	.001	2	view →
READ	All	All	+0.657	.025	1	view →
THCA	Male	III,IV	−0.477	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TIGD4–KICH

Open the KICH breakdown →