TIGAR

Across TCGA patient cohorts, TIGAR mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGAR-associated genes across cancer lineages are Notch1, FOXO3a_pS318_S321, and Myosin-IIa_pS1943. Each is linked with TIGAR in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGAR-to-partner and partner-to-TIGAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TIGAR-low versus TIGAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGAR→partner) and Y-score (partner→TIGAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+2.321	.032	.035	3	2
UCEC	FOXO3a_pS318_S321 →	-0.148	-3.160	.018	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.327	+2.335	.001	.020	3	1
UCEC	p62 Lck ligand →	+0.592	+3.179	<.001	.010	3	1
UCEC	Rab11 →	-0.191	-3.459	.008	.005	3	1
UCEC	Rad50 →	-0.262	-2.321	.031	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Notch1 by TIGAR expression — UCEC

Explore this box plot interactively →