TIGAR

Across TCGA pan-cancer cohorts, TIGAR RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TIGAR data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TIGAR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TIGAR expression acts as an unfavorable survival marker, although some lineages such as STAD and BRCA show a favorable association.

MESO, ACC, and LGG are the cancer types where TIGAR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.258	0.508	<.001	69	view →
ACC	OS	Median	All	0.776	0.961	<.001	68	view →
LGG	OS	Median	All	0.708	0.909	<.001	53	view →
COAD	DFS	Tertile	IV	0.295	0.668	.001	45	view →
LAML	DFS	Median	All	0.344	0.581	<.001	36	view →
STAD	DFS	Quartile	II,III,IV	0.727	0.512	.008	30	view →
KIRC	DFS	Tertile	III,IV	0.517	0.707	.017	20	view →
OV	OS	Quartile	III,IV	0.735	0.855	.011	18	view →
UVM	OS	Median	III,IV	0.407	0.858	.006	18	view →
LUSC	DFS	Quartile	II,III,IV	0.481	0.799	.021	17	view →
BRCA	DFS	Quartile	IV	0.754	0.144	.031	14	view →
LIHC	OS	Quartile	All	0.537	0.697	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TIGAR–MESO (OS)

Open the MESO breakdown →