TIGAR

Across TCGA pan-cancer cohorts, TIGAR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TIGAR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TIGAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIGAR is over-expressed in tumor.

HNSC, STAD, and LIHC are the cancer types where TIGAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIGAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.024	<.001	12	view →
STAD	Female	All	+1.319	<.001	9	view →
LIHC	Female	II,III,IV	+0.910	<.001	9	view →
UCEC	All	II,III,IV	+1.447	<.001	6	view →
COAD	All	II,III,IV	+0.592	<.001	6	view →
ESCA	All	All	+1.073	<.001	5	view →
KIRP	All	II,III,IV	+0.664	.011	5	view →
READ	All	II,III,IV	+0.967	.023	4	view →
BRCA	All	All	+0.415	<.001	4	view →
CHOL	All	All	+1.661	<.001	3	view →
THCA	All	All	+0.340	.002	2	view →
LUSC	All	All	+0.320	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TIGAR–HNSC

Open the HNSC breakdown →