TIGAR

Across TCGA cell cohorts, TIGAR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,857 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIGAR-associated GO terms across cancer lineages are Positive regulation of pentose-phosphate shunt, Regulation of pentose-phosphate shunt, and Regulation of NADP metabolic process. Each is linked with TIGAR in more than 17 cancer types. Because this analysis shows association rather than direction, both TIGAR-to-partner and partner-to-TIGAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of pentose-phosphate shunt grouped by TIGAR-low versus TIGAR-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGAR→partner) and Y-score (partner→TIGAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of pentose-phosphate shunt →	+0.208	+1.258	<.001	<.001	3	18
KIDNEY	Regulation of pentose-phosphate shunt →	+0.187	+1.325	<.001	<.001	3	16
BREAST	Regulation of NADP metabolic process →	+0.151	+1.151	<.001	.003	3	15
URINARY_TRACT	Positive regulation of G0 to G1 transition →	+0.213	+1.106	.001	.001	2	11
OESOPHAGUS	Positive regulation of rRNA processing →	+0.126	+0.728	.002	.006	3	9
BLOOD_Myeloma	Cellular response to cobalt ion →	+1.090	+1.046	.002	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,857 associations by consensus.

Positive regulation of pentose-phosphate shunt by TIGAR expression — SKIN

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