THSD7B

Across TCGA patient cohorts, THSD7B mutation is significantly associated with the RNA expression of many other genes, with 7,661 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THSD7B-associated genes across cancer lineages are PROSER1, WDR72, and DIABLO. Each is linked with THSD7B in more than 4 cancer types. Because this analysis shows association rather than direction, both THSD7B-to-partner and partner-to-THSD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROSER1 grouped by THSD7B-low versus THSD7B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD7B→partner) and Y-score (partner→THSD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PROSER1 →	+0.632	+3.189	.001	.008	3	5
SKCM	WDR72 →	+0.341	+0.603	.001	.004	3	5
UCEC	DIABLO →	+0.310	+1.726	<.001	<.001	3	5
LUAD	FBRSL1 →	+0.453	+1.893	<.001	<.001	3	5
LUAD	HELLS →	+0.588	+2.193	<.001	<.001	3	5
UCEC	COPS7B →	+0.222	+1.861	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,661 associations by consensus.

PROSER1 by THSD7B expression — CESC

Explore this box plot interactively →