THSD7B

Across TCGA pan-cancer cohorts, THSD7B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of THSD7B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where THSD7B RNA is repressed in tumor relative to normal tissue. In most cancer types THSD7B is over-expressed in tumor, although a few such as BLCA and BRCA show the opposite, repressed pattern.

BLCA, BRCA, and KIRP are the cancer types where THSD7B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THSD7B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.639	<.001	10	view →
BRCA	All	All	−1.115	<.001	6	view →
KIRP	Female	All	−0.954	<.001	5	view →
KIRC	Male	All	−0.393	.003	5	view →
ESCA	All	II,III,IV	+0.950	.039	2	view →
PRAD	All	All	−0.391	.007	2	view →
LUSC	All	All	+0.364	.009	1	view →
THCA	Male	II,III,IV	−0.333	.044	1	view →
LUAD	All	All	+0.234	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

THSD7B–BLCA

Open the BLCA breakdown →