Across TCGA cell cohorts, THSD4 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible THSD4-associated genes across cancer lineages are FCRL4, CENPVL1, and CCR8. Each is linked with THSD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both THSD4-to-partner and partner-to-THSD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD4→partner) and Y-score (partner→THSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FCRL4 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	CENPVL1 →	+0.246	+4.906	<.001	.006	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	GPR139 →	+0.032	+4.369	<.001	.008	3	1
SOFT_TISSUE	SERPINB11 →	+0.839	+4.222	<.001	.007	3	1
BLOOD_Leukemia	C8B →	+0.292	+4.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

THSD4 survival (RNA) · tumor vs normal (RNA) · all THSD4 data types