Across TCGA pan-cancer cohorts, THSD4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated THSD4 data layer compared with 9 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher THSD4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated THSD4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.
BRCA, SCLC, and KIRP are the cancer types where THSD4 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.