Across TCGA cell cohorts, THSD4 mutation is significantly associated with the mutation status of many other genes, with 4,280 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THSD4-associated genes across cancer lineages are CACNA1F, ARHGAP39, and IARS1. Each is linked with THSD4 in more than 4 cancer types. Because this analysis shows association rather than direction, both THSD4-to-partner and partner-to-THSD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THSD4→partner) and Y-score (partner→THSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CACNA1F →	+5.000	+4.044	.008	.008	1	5
OVARY	ARHGAP39 →	+3.240	+4.467	.004	.004	1	5
CNS	IARS1 →	+5.000	+4.044	.008	.008	1	4
CNS	HSF1 →	+5.000	+4.044	.008	.008	1	4
CNS	NRG3 →	+5.000	+4.044	.008	.008	1	4
LUNG_NSCLC_LUAD	TOGARAM1 →	+3.851	+3.263	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,280 associations by consensus.

Exploration

THSD4 survival (RNA) · tumor vs normal (RNA) · all THSD4 data types