THPO

Across TCGA patient cohorts, THPO mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THPO-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and MEK1. Each is linked with THPO in more than 2 cancer types. Because this analysis shows association rather than direction, both THPO-to-partner and partner-to-THPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by THPO-low versus THPO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THPO→partner) and Y-score (partner→THPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.457	-1.765	.007	.014	3	3
UCEC	Caspase-7-cleavedD198 →	+0.837	+2.341	<.001	.003	3	3
UCEC	MEK1 →	+0.327	+2.169	.017	.003	3	2
UCEC	MSH2 →	-0.232	-1.848	.007	.049	3	2
UCEC	PDCD4 →	-0.695	-2.797	<.001	.003	3	2
UCEC	C-Raf →	+0.151	+2.807	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by THPO expression — UCEC

Explore this box plot interactively →