THPO

Across TCGA pan-cancer cohorts, THPO RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated THPO data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher THPO RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated THPO expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

UVM, ACC, and KIRP are the cancer types where THPO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.370	0.651	<.001	102	view →
ACC	DFS	Median	All	0.280	0.615	<.001	87	view →
KIRP	DFS	Tertile	III,IV	0.106	0.862	.001	38	view →
STAD	OS	Tertile	All	0.512	0.669	.008	30	view →
SCLC	OS	Tertile	IV	0.959	0.274	.010	24	view →
UCS	DFS	Tertile	IV	0.419	0.932	.024	24	view →
KIRC	DFS	Quartile	All	0.502	0.773	.009	18	view →
BLCA	OS	Median	All	0.559	0.656	.024	14	view →
COAD	DFS	Tertile	All	0.737	0.831	.009	13	view →
LUSC	DFS	Tertile	II,III,IV	0.286	0.479	.006	12	view →
CHOL	DFS	Quartile	All	0.308	0.788	.006	11	view →
MESO	DFS	Quartile	III,IV	0.346	0.600	.015	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

THPO–UVM (DFS)

Open the UVM breakdown →