THPO

Across TCGA pan-cancer cohorts, THPO RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of THPO’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where THPO RNA is repressed in tumor relative to normal tissue. In most cancer types THPO is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, BRCA, and UCEC are the cancer types where THPO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THPO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.614	<.001	11	view →
BRCA	All	III,IV	+1.055	<.001	6	view →
UCEC	All	All	−0.866	<.001	6	view →
LUAD	All	All	+0.625	<.001	5	view →
CHOL	All	All	−1.865	.004	4	view →
KIRP	All	All	−0.833	.007	4	view →
KIRC	Female	All	+0.756	.034	2	view →
LIHC	All	III,IV	+0.657	.003	2	view →
PRAD	All	All	+0.566	<.001	2	view →
HNSC	Female	All	+0.240	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

THPO–KICH

Open the KICH breakdown →