THPO

Across TCGA cell cohorts, THPO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,699 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible THPO-associated GO terms across cancer lineages are Positive regulation of hematopoietic stem cell proliferation, Regulation of potassium ion transport, and Regulation of membrane repolarization. Each is linked with THPO in more than 7 cancer types. Because this analysis shows association rather than direction, both THPO-to-partner and partner-to-THPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of hematopoietic stem cell proliferation grouped by THPO-low versus THPO-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THPO→partner) and Y-score (partner→THPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of hematopoietic stem cell proliferation →	-0.184	-1.433	<.001	.003	3	8
LIVER	Regulation of potassium ion transport →	-0.137	-2.137	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of membrane repolarization →	-0.188	-0.275	<.001	.004	3	7
OESOPHAGUS	Cardiac conduction →	-0.152	-0.479	.001	.005	3	7
OESOPHAGUS	Potassium ion import across plasma membrane →	-0.221	-0.483	<.001	.006	3	7
OVARY	Chordate pharynx development →	+1.375	+0.626	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,699 associations by consensus.

Positive regulation of hematopoietic stem cell proliferation by THPO expression — LUNG_SCLC

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