THPO

Across TCGA cell cohorts, THPO mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible THPO-associated genes across cancer lineages are GLOD5, CCL19, and USP17L8. Each is linked with THPO in more than 1 cancer types. Because this analysis shows association rather than direction, both THPO-to-partner and partner-to-THPO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLOD5 grouped by THPO-low versus THPO-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THPO→partner) and Y-score (partner→THPO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GLOD5 →	+0.071	+5.217	<.001	<.001	3	1
SKIN	CCL19 →	+0.041	+4.415	.002	.007	3	1
SKIN	USP17L8 →	+0.005	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GLOD5 by THPO expression — SKIN

Explore this box plot interactively →