THOC3

Across TCGA cell cohorts, THOC3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THOC3-associated genes across cancer lineages are OR10W1, OR10Q1, and EPPIN. Each is linked with THOC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THOC3-to-partner and partner-to-THOC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by THOC3-low versus THOC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THOC3→partner) and Y-score (partner→THOC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	OR10Q1 →	+0.105	+3.920	.002	.005	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	SPHKAP →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR52E4 →	+0.022	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR10W1 by THOC3 expression — LARGE_INTESTINE

Explore this box plot interactively →