THEM6

Across TCGA patient cohorts, THEM6 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,424 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THEM6-associated proteins across cancer lineages are SCRIB, PPP1R18, and PYCR3. Each is linked with THEM6 in more than 5 cancer types. Because this analysis shows association rather than direction, both THEM6-to-partner and partner-to-THEM6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THEM6 versus SCRIB in BRCA, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM6→partner) and Y-score (partner→THEM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCRIB →	+0.334	+0.700	<.001	.001	3	6
LSCC	PPP1R18 →	-0.325	-0.567	<.001	<.001	3	6
BRCA	PYCR3 →	+0.527	+1.055	<.001	<.001	3	5
BRCA	ESRP1 →	+0.503	+0.887	<.001	<.001	3	5
GBM	MICAL1 →	-0.347	-0.360	<.001	.004	3	5
BRCA	MTERF3 →	+0.459	+1.097	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,424 associations by consensus.

THEM6 vs SCRIB — BRCA

Explore this scatter interactively →