THEM6

Across TCGA pan-cancer cohorts, THEM6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of THEM6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where THEM6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THEM6 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

COAD, STAD, and LIHC are the cancer types where THEM6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THEM6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.849	<.001	12	view →
STAD	Male	III,IV	+2.331	<.001	8	view →
LIHC	Male	III,IV	+1.622	<.001	8	view →
BLCA	All	III,IV	+1.362	.002	8	view →
THCA	Male	III,IV	−0.684	<.001	8	view →
READ	Female	All	+1.641	<.001	7	view →
UCEC	All	All	+1.086	<.001	6	view →
BRCA	All	II,III,IV	+0.587	<.001	6	view →
CHOL	Female	All	+1.343	<.001	4	view →
PAAD	All	All	+0.960	.018	2	view →
KIRP	Male	All	−0.526	<.001	2	view →
PRAD	All	All	+0.424	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

THEM6–COAD

Open the COAD breakdown →