THEM6

Across TCGA patient cohorts, THEM6 protein abundance is significantly associated with the RNA expression of many other genes, with 8,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THEM6-associated genes across cancer lineages are SHARPIN, DGAT1, and PYCR3. Each is linked with THEM6 in more than 5 cancer types. Because this analysis shows association rather than direction, both THEM6-to-partner and partner-to-THEM6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THEM6 versus SHARPIN in LUAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM6→partner) and Y-score (partner→THEM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SHARPIN →	+0.731	+0.481	<.001	<.001	3	6
OV	DGAT1 →	+0.598	+0.391	.001	<.001	3	6
LSCC	PYCR3 →	+0.749	+0.404	<.001	<.001	3	5
COAD	SLC39A4 →	+0.923	+0.314	<.001	<.001	3	5
OV	CYC1 →	+0.839	+0.450	.001	<.001	3	5
LSCC	ANKRD46 →	+0.639	+0.281	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,830 associations by consensus.

THEM6 vs SHARPIN — LUAD

Explore this scatter interactively →