THEM6

Across TCGA cell cohorts, THEM6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,696 significant associations in total. BONE shows the largest number of these associations.

The most reproducible THEM6-associated GO terms across cancer lineages are Positive regulation of voltage-gated potassium channel activity, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, and Malate transmembrane transport. Each is linked with THEM6 in more than 11 cancer types. Because this analysis shows association rather than direction, both THEM6-to-partner and partner-to-THEM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of voltage-gated potassium channel activity grouped by THEM6-low versus THEM6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEM6→partner) and Y-score (partner→THEM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of voltage-gated potassium channel activity →	+1.116	+1.292	<.001	<.001	3	12
STOMACH	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	-0.094	-1.326	<.001	<.001	3	10
BONE	Malate transmembrane transport →	+0.262	+1.723	<.001	<.001	3	9
BONE	Cellular response to nitrosative stress →	-0.180	-1.315	.001	.004	3	9
BONE	Malate transport →	+0.262	+1.723	<.001	<.001	3	9
BLOOD_Lymphoma	Regulation of collagen metabolic process →	-0.089	-0.734	<.001	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,696 associations by consensus.

Positive regulation of voltage-gated potassium channel activity by THEM6 expression — BREAST

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