THEGL

Across TCGA patient cohorts, THEGL RNA expression is significantly associated with the go_rna of many other GO terms, with 7,130 significant associations in total. STAD shows the largest number of these associations.

The most reproducible THEGL-associated GO terms across cancer lineages are Microtubule polymerization, Regulation of proteolysis involved in protein catabolic process, and Positive regulation of mRNA metabolic process. Each is linked with THEGL in more than 27 cancer types. Because this analysis shows association rather than direction, both THEGL-to-partner and partner-to-THEGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization grouped by THEGL-low versus THEGL-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEGL→partner) and Y-score (partner→THEGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Microtubule polymerization →	+0.057	+0.299	<.001	<.001	3	28
ESCA	Regulation of proteolysis involved in protein catabolic process →	+0.082	+0.263	<.001	.002	3	26
ESCA	Positive regulation of mRNA metabolic process →	+0.081	+0.376	<.001	<.001	3	26
STAD	Vacuole organization →	+0.069	+0.301	<.001	<.001	3	26
STAD	Regulation of microtubule polymerization or depolymerization →	+0.055	+0.298	<.001	<.001	3	25
STAD	TORC1 signaling →	+0.071	+0.281	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,130 associations by consensus.

Microtubule polymerization by THEGL expression — STAD

Explore this box plot interactively →