THEGL

Across TCGA pan-cancer cohorts, THEGL RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated THEGL data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher THEGL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated THEGL expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

KIRC, LGG, and CESC are the cancer types where THEGL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.508	0.686	<.001	103	view →
LGG	DFS	Median	All	0.654	0.809	<.001	54	view →
CESC	OS	Quartile	III,IV	0.128	0.594	.009	42	view →
KICH	OS	Tertile	III,IV	0.212	0.913	.004	39	view →
CHOL	OS	Quartile	All	0.466	0.800	.018	35	view →
DLBC	DFS	Tertile	All	0.386	0.855	.006	33	view →
COAD	DFS	Tertile	All	0.690	0.811	.011	27	view →
UCS	OS	Quartile	II,III,IV	0.635	0.173	.033	18	view →
ACC	OS	Median	All	0.905	0.706	.011	18	view →
BLCA	DFS	Quartile	II,III,IV	0.434	0.548	.023	17	view →
READ	DFS	Quartile	IV	0.270	0.634	.005	11	view →
ESCA	DFS	Median	All	1.000	0.519	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

THEGL–KIRC (OS)

Open the KIRC breakdown →