THEGL

Across TCGA pan-cancer cohorts, THEGL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of THEGL’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where THEGL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THEGL is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

LUAD, LUSC, and HNSC are the cancer types where THEGL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THEGL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.225	<.001	7	view →
LUSC	Male	All	+0.162	<.001	5	view →
HNSC	All	All	+0.096	.003	5	view →
KIRC	All	II,III,IV	−0.024	<.001	5	view →
BRCA	All	All	−0.039	.009	4	view →
KIRP	Female	All	+0.069	.009	3	view →
BLCA	Male	IV	−0.617	.019	2	view →
PAAD	Male	All	−0.155	.047	2	view →
PRAD	All	All	−0.071	.019	2	view →
THCA	All	All	+0.030	.027	2	view →
READ	All	All	−0.132	.046	1	view →
COAD	Male	All	−0.072	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

THEGL–LUAD

Open the LUAD breakdown →