THEGL

Across TCGA cell cohorts, THEGL mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THEGL-associated genes across cancer lineages are OPN4, MSGN1, and TAFA1. Each is linked with THEGL in more than 1 cancer types. Because this analysis shows association rather than direction, both THEGL-to-partner and partner-to-THEGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPN4 grouped by THEGL-low versus THEGL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEGL→partner) and Y-score (partner→THEGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OPN4 →	+0.013	+4.930	.007	.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.089	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.418	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MINAR2 →	+0.053	+4.467	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MS4A18 →	+0.022	+4.095	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OPN4 by THEGL expression — LARGE_INTESTINE

Explore this box plot interactively →