THBD

Across TCGA patient cohorts, THBD mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THBD-associated genes across cancer lineages are RNA5SP54, MTHFD2P5, and SLCO1B3-SLCO1B7. Each is linked with THBD in more than 2 cancer types. Because this analysis shows association rather than direction, both THBD-to-partner and partner-to-THBD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP54 grouped by THBD-low versus THBD-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THBD→partner) and Y-score (partner→THBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP54 →	+0.623	+7.930	<.001	.008	3	3
UCEC	MTHFD2P5 →	+0.132	+2.413	<.001	.001	3	2
STAD	SLCO1B3-SLCO1B7 →	+0.222	+3.689	<.001	.007	3	2
BLCA	HMGB1P12 →	+0.115	+5.018	.007	.004	3	2
COAD	SNORD113-4 →	+0.586	+2.956	<.001	.004	3	1
COAD	SDC4P →	+0.065	+3.061	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

RNA5SP54 by THBD expression — LUAD

Explore this box plot interactively →